Ah, that would explain the discrepancy. Spoiler alert: ASD in adults was estimated to be 1%. . One just needs to consider a model where a brain is a complicated object whose organization and function depends on changes in the genetic blueprint in non-monotonic ways, and it is likely that all combinations (attainable via sexual reproduction) of genes that are beneficial alone or in some particular arrangements are not even more beneficial together; some of the potential arrangements are bound to be non-optimal or even catastrophic. I really like this change. g_i = 1 if the parameter is present, g_i = 0 if not. I actually find it rather consistent with the idea that our brain chemistry is tuned to work with a given level of hormones/neurotransmitters produced by our gut bacteria as per Maybe Your Zoloft Stopped Working Because A Liver Fluke Tried To Turn Your Nth-Great-Grandmother Into A Zombie. Im not a great student of philosophy, but I dont think most modern philosophers look at the writings of Plato or Descartes or Kant or Hume and think they were intellectual lightweights. This can best be understood through a tower-versus-foundation model where higher intelligence that outstrips the ability of some mysterious foundation to support it will result in autism (25% confidence), 6. Slightly differently: Being gifted makes it harder to take certain things seriously. There are huge practical and financial incentives within our system to diagnose all of these sets of kids with some kind of medicalized disorder, regardless of whether any underlying physical mechanism is understood or present (and sometimes it is, but many different developmental issues can lead you down each of these roads). for which certain genetic inputs might be extremely valuable but there are numerous different ways to arrive at the end point of being good at the game, and numerous different ways that even people genetically gifted in some important capacity can end up being bad at playing the overall game. Suppose also that these autism spectrum traits are associated with negative outcomes such as mental retardation, social nonfunction, etc. Now imagine that someone was in that condition but *couldnt* turn it off. It would be an excellent skill for a teacher. Intelligence may be very much the same way. I recall it because the lowest functioning children all had loser fathers. And autistic people have more health issues than non-autistic people do. These deficits are present in early childhood, typically before age three, and lead to clinically significant functional impairment. Theres a range for this parameter, selection in the past has left most of the population too low, but if you push the parameter up too high things will break. And thus a little more involvement from the microglia in utero or during early childhood might lead to a more efficient neural configuration and a higher IQ, especially if the involvement is more concentrated in the brain regions with more of an evolutionarily enforced margin toward resilience/survival rather than cognitive performance in normal humans. We were grouped with autistic including low functioning autistics. Our ages when our son (1st child) was born were 27 (me) and 26 (my wife), and for our daughter (3rd child) we were 31 and 30. If females have a higher average baseline social competence, it would stand to reason that even the impaired girls would remain above the diagnosis threshold in greater numbers. That figure seems very low to me, though it depends what exactly you define as incredibly smart and incredibly charismatic. If we take incredibly to be synonymous with top percentile, there would be 75 million people in the world who are incredibly intelligent. But they offer a way of grouping types of problem kids that has caught on. Probably wrong ideas generated from your writing here: We know that core elements of cognition not only do develop early in life, but *have* to develop in life. Overall scores could continue to rise due to the Flynn effect even as intelligence is being selected against on a genetic level, which is what the evidence is suggesting. It would explain the association of genes for intelligence with autism (holding foundation strength constant, the taller the tower, the more likely a failure). If its just intelligence is good up to some point, then you get autism, how do you explain intelligence sometimes going way past that point without autism? 4. Because they lacked the development of the auditory processing, it was very draining for them because it mostly came across as a large amount of noise. Girls also get autism, but seem to stay undiagnosed much more often. I think an important possibility to consider is that some or all of the correlation were observing is simply due to bias in the data were using, rather than any actual relationship between high IQ and autism. Meanwhile, placing people on the spectrum equalizes access to resources, including insurance coverage. Many people she knew, she said, felt duped by psychiatrists, for example, who they felt. What is the SES variation of autism? Because a masculinizing influence on the brain would militate against the development of brain structures telling the autistic person you are actually a girl.. Say you are a bright nerdy tech-aligned person who is attracted to other bright nerdy tech-aligned people; you have a medium preference for eventually having kids but you really dont want an autistic child. do people predisposed to have autistic kids tend to have them later? Perhaps it will help if I ask a question. The line here has an extra close-paragraph symbol, > (though see the discussion here) for some debate over how seriously to take this; I am less sure this is accurate than most of the other statistics mentioned here), which I assume is the one missing from the later section here. I have read before that age of parents increases risk of autism. These mutations are often very bad, and are quickly selected out of the gene pool (because the people who have them dont reproduce). FWIW, I know a few bona-fide genius-level people; on the order of Ph.D. surveyed ~4000 MENSA members and found that in addition to being at a signficant increase in risk not just in ASDs and mood disorders but also in food allergies, asthma and 2x RR of autoimmune conditions compared to the general population. Epistemic status: wild speculation backed up only by anecdotal evidence and theory. The population mean for many of those parameters is off from the optimal value for thinking, perhaps because theres some tradeoff encoded there that doesnt matter as much now as in the past. Getting more education is strongly correlated with later childbearing / siring. (All three were C-section births.) Big muscles can also reduce range of motion. ASD has no reliable early predictor, no unitary developmental course, no unitary life outcome, no unitary recurrence risk, no unitary pattern of BAP features, and no standard homogeneous subgroups. He has the making of a superb engineer. These different enrichment profiles observed provide evidence for a heterogeneous and qualitatively different genetic architecture between sub-types of ASD, which should inform future studies aiming at identifying etiologies and disease mechanisms in ASD. But African slaves survived. She has absolute pitch, [] an amazingly high proportion of her autistic students have it to some degree. In Graph A, we see that if a child has autism (but not intellectual disability), their likelihood of having a father with any particular IQ (orange line) is almost the same as the likelihood of a neurotypical child having a father of that IQ (dotted line). Ive since backed off of it a bit, maybe not because I think its wrong but because theres possibly a larger and more interesting explanation for what we see, which is that both the collection of deficits that go with low-functioning ASD and the neural efficiencies that go with high IQ are both at least partially caused by a twitchier immune system, which in turn is creating a different profile of synaptic pruning as the brain develops. Preoccupation with whats normal and whether you are normal is a sign of mediocrity in my experience (though its not terminal). Thus it is perhaps unsurprising that our data suggests that the contribution of common variants may be more prominent in high-functioning ASD cases such as Aspergers syndrome. The post is laden with unsaid assumptions that do not make sense to me. The damn thing has basically come true! There is then a threshold effect with enough perceptual ability and intelligence, the developing brain finds ways to route around the broken normal processes to get stuff done. Altruisto is a browser extension so that when you shop online, a portion of the money you pay goes to effective charities (no extra cost to you). Kraus et al. This friend had been working for many years with Leroy Hood. my kid who is on the spectrum is 12 and ok functioning (doing well in middle school) i cant imagine what would get us into the therapist office to do an IQ test. Fall short of that threshold and you have a pile of severely broken processes. ASD core diagnostic symptoms are not uniquely linked and are only very rarely expressed without nondiagnostic symptoms. Thats assuming that we do have a missing group of geniusesIm not sure how we track these things, or who you are counting as a genius. There is also some link to male sex, I do believe that there are higher levels of males with low intelligence autism. One solution is to view your family rather than your schoolmates as your peer group. The Gardner study seems to suggest its a very weakly elevated risk, maybe only 1.1x or 1.2x relative risk. Below are two lists taken from an autism checklist and a reactive attachment disorder list. And that finds that only 15% have intellectual disabilities. If genes for autism (without autism itself) increase intelligence, we should expect these people to be unusually smart. Well, much debate here gets into the distinction between people with high functioning autism and Aspergers, due to a muddling at that end of the scale. A bit of motivation before asking a question: my boss has a daughter. In primary school, for a while we used to have daily spelling tests, where we had to spell ten words. This fear is reinforced by the fact that of my 12 cousins, 1 is severely autistic, another one is autistic, but can function, 2 are diagnosed aspie and another 1 is an edge-case. n=1, but it was striking to watch my very smart middle kid go from being a near-outcast in his good Catholic school to a guy with lots of friends at his magnet school. 6 6 6 6 6 marries 6 6 6 6 6, decent chance of getting a 9 9 8 7 9 stone cold genius. If the curve stayed exactly the same and there was a correlation between IQ > arb. As a practical matter of course these disorder clusters can easily overlap and often do, as seen in the most recent DSM when they allowed co-diagnosis of autism and ADHD for the first time (by popular demand pretty much!). Thats probably how he got to that level. Non-verbal people requiring institutionalization? Or in the case of plants, their leaf structures are generated by a fractal pattern, and even small changes in the parameters of that fractal cause large changes in the ultimate pattern in a way that is chaotic and difficult to predict. She was born with the cord around her neck, and we had respiratory specialists on hand to assist. Etc. Social rituals are incredibly important though, humans are social animals. Increasing numbers of autistic kids at the high end, as some of the smart kids get too many overlapping IQ-enhancing genes that mess up something important. I am getting a vision of the future. This shows a) there isnt much of a childhood autism epidemic going on, its more likely that previous underdiagnosis occurred. The normies were not spergs running emulations, theyd have the same confused look whenever we sperged-out about something that we had when they talked about sportsball. The genes that control the development of that definitely dont do so in a linear or easily explainable way. More, you have probably already settled into an existence that minimizes their importance to you by the time you have enough information to piece together the importance of predictability. I always used to get one word wrong on purpose because I preferred the silver stars. I have a day job and SSC gets free hosting, so don't feel pressured to contribute. [3] The Tower vs Foundation model seems to treat intelligence as if its an attribute like height or arm length; the modification of some static variable. Plenty of people are both smarter and more charismatic than us. I am not particularly confident in the theory either in its parts or in whole. About 13% of autistic children (in this sample from whatever social stratum they took their sample from) have fathers who are engineers, compared to only 5% of a group of (presumably well-matched?) This model predicts something I believe is true many low functioning autistic people have real talents lurking in there, it is just really hard for them or others to access those talents because of all the broken stuff. the genetic load would be due to bad luck in parent mixing (recessive-recessive pairs) and parent age. Moreover, if your family isnt too bright, you might not even recognize that theres something funny about your latest kid. If the mums with low functioning autistic children, the ones I spoke to described the fathers as losers or deadbeats. I mean, doesnt that just mean there are lots of hyper-parameters and you can push one set outside the optimal range without maxing out everything? autism polygenic risk scores attached to Tinder profiles Like many DSM diagnoses it is a junkheap of often unrelated symptoms wrapped up in a single label for essentially politically reasons. So for example, bench is largely worthless if youre not pushing people away from you. Ok, I just got to the end of the comments and no-one else has brought this up yet: Isnt the finding that why is the medical establishment making confident claims regarding the connection between his condition and high-functioning autism? Perhaps something similar but more extreme is true of autism: maybe autistic people are more highly represented at both ends of the IQ distribution. Some of this effect is because autism is caused both by normal genes and by de novo mutations and environmental insults, and the de novo mutations and environmental insults definitely decrease intelligence. Can we quantify the causality going the other way? Norwegian founders with an international team on a mission to offer the equivalent of a Norwegian social safety net globally available as a membership. Their career progress might have stalled due to stress and sleep deprivation. Bottle. This makes a very strong auditory learner. There are a lot more pathways to leveraging raw intelligence to acquire economic status now than there used to be, but very few that get you all the way to the point that youre fully safe from the tribe (since the tribe is now the nation and is thus also much stronger now).
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